Communications Biology (Apr 2022)
Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness
- Andrea I. Luppi,
- Pedro A. M. Mediano,
- Fernando E. Rosas,
- Judith Allanson,
- John D. Pickard,
- Guy B. Williams,
- Michael M. Craig,
- Paola Finoia,
- Alexander R. D. Peattie,
- Peter Coppola,
- Adrian M. Owen,
- Lorina Naci,
- David K. Menon,
- Daniel Bor,
- Emmanuel A. Stamatakis
Affiliations
- Andrea I. Luppi
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- Pedro A. M. Mediano
- Department of Psychology, University of Cambridge
- Fernando E. Rosas
- Center for Psychedelic Research, Department of Brain Science, Imperial College London
- Judith Allanson
- Department of Clinical Neurosciences, University of Cambridge
- John D. Pickard
- Department of Clinical Neurosciences, University of Cambridge
- Guy B. Williams
- Department of Clinical Neurosciences, University of Cambridge
- Michael M. Craig
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- Paola Finoia
- Department of Clinical Neurosciences, University of Cambridge
- Alexander R. D. Peattie
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- Peter Coppola
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- Adrian M. Owen
- The Brain and Mind Institute, University of Western Ontario
- Lorina Naci
- Trinity College Institute of Neuroscience, Trinity College Dublin
- David K. Menon
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- Daniel Bor
- Department of Psychology, University of Cambridge
- Emmanuel A. Stamatakis
- Division of Anaesthesia, School of Clinical Medicine, University of Cambridge
- DOI
- https://doi.org/10.1038/s42003-022-03330-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Perturbations in a large-scale whole-brain model suggest that anesthesia and injury may be imparting functionally similar effects in terms of brain dynamics.
