Фармакокинетика и Фармакодинамика (Apr 2014)
Comparison of behavioral and neuro-receptor effects of pantogam and bemitil with single and multiple injections in mice of C57BL/6 and BALB/c
Abstract
The effect of single and multiple modes of administration pantogam (pantokaltsina) and bemitil (metaprot) on the dynamics of nootropic specific and nonspecific behavioral effects of anxiolytic drugs and their possible association with NMDA- and benzodiazepine receptors in the brain of inbred C57BL/6 and BALB/c. The line BALB/c is characterized by decreased compared to mice C57BL/6 baseline levels of cognitive and emotional status, NMDA- and benzodiazepine receptors in the hippocampus and the prefrontal cortex, and therefore has been used as a non-invasive model of deficit manifestations of these functions. Under the influence of acute, 7- and 14-fold administration pantogam (200 mg/kg/day intraperitoneally) in BALB/c mice was observed slow increase in NMDA-receptors and slow rise specific effect characteristic nootropics. Anxiolytic effect of the drug in mice BALB/c and C57Bl/6 was not detected, however, the line C57Bl/6 showed an increase in the density of benzodiazepine receptor in the first week and by the end of the experiment density reduction below the control was observed in both lines. Under the influence of acute, 7- and 14-fold bemitil administration (25 mg/kg/day intraperitoneally) in BALB / c mice at an early stage of the experiment there was a rapid increase in NMDA-receptors and efficiency of exploratory behavior, disappearing in the following days. The observed dynamics quickly realized most likely is not unique nootropic and psychoactive component of the pharmacological effect of the drug. Anxiolytic effect developed during the first week indiscriminately for both lines, however, decrease benzodiazepine reception detected at day 14 in both lines.
