Journal of Hematology & Oncology (Sep 2016)
Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
- Zhiwu Jiang,
- Manman Deng,
- Xinru Wei,
- Wei Ye,
- Yiren Xiao,
- Simiao Lin,
- Suna Wang,
- Baiheng Li,
- Xin Liu,
- Gong Zhang,
- Peilong Lai,
- Jianyu Weng,
- Donghai Wu,
- Haijia Chen,
- Wei Wei,
- Yuguo Ma,
- Yangqiu Li,
- Pentao Liu,
- Xin Du,
- Duanqing Pei,
- Yao Yao,
- Bing Xu,
- Peng Li
Affiliations
- Zhiwu Jiang
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Manman Deng
- Department of Hematology, The First Affiliated Hospital of Xiamen University
- Xinru Wei
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Wei Ye
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Yiren Xiao
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Simiao Lin
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Suna Wang
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Baiheng Li
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xin Liu
- Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Gong Zhang
- Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Peilong Lai
- Department of Hematology, Guangdong Provincial People’s Hospital
- Jianyu Weng
- Department of Hematology, Guangdong Provincial People’s Hospital
- Donghai Wu
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Haijia Chen
- Guangzhou SALIAI Stem Cell Science and Technology Co. Ltd
- Wei Wei
- Guangdong Cord Blood Bank
- Yuguo Ma
- Yikang Tailai Technology Co. Ltd
- Yangqiu Li
- Department of Hematology, Medical College, Jinan University
- Pentao Liu
- Wellcome Trust Sanger Institute
- Xin Du
- Department of Hematology, Guangdong Provincial People’s Hospital
- Duanqing Pei
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Yao Yao
- Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Bing Xu
- Department of Hematology, The First Affiliated Hospital of Xiamen University
- Peng Li
- State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1186/s13045-016-0310-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 5
Abstract
Abstract The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.
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