ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Davide Esposito; Ila Pant; Yao Shen; Rui F. Qiao; Xiaobao Yang; Yiyang Bai; Jian Jin; Poulikos I. Poulikakos; Stuart A. Aaronson

doi:10.1038/s41467-022-28319-3

Nature Communications (Feb 2022)

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Davide Esposito,
Ila Pant,
Yao Shen,
Rui F. Qiao,
Xiaobao Yang,
Yiyang Bai,
Jian Jin,
Poulikos I. Poulikakos,
Stuart A. Aaronson

Affiliations

Davide Esposito: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Ila Pant: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Yao Shen: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Rui F. Qiao: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Xiaobao Yang: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Yiyang Bai: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Jian Jin: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Poulikos I. Poulikakos: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Stuart A. Aaronson: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-022-28319-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Crosstalk between the p53 and Hippo pathway has been reported in different physiological contexts. Here, the authors show that p53 DNA contact mutations upregulate TEAD/YAP transcription indirectly and transform cells via hyperactivation of RhoA/ROCK/actomyosin signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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