Frontiers in Immunology (Jan 2024)
Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects
- Chunjia Zhang,
- Chunjia Zhang,
- Yan Li,
- Yan Yu,
- Zehui Li,
- Zehui Li,
- Xin Xu,
- Xin Xu,
- Zuliyaer Talifu,
- Wubo Liu,
- Wubo Liu,
- Wubo Liu,
- Degang Yang,
- Degang Yang,
- Feng Gao,
- Feng Gao,
- Song Wei,
- Song Wei,
- Liang Zhang,
- Liang Zhang,
- Han Gong,
- Han Gong,
- Run Peng,
- Run Peng,
- Liangjie Du,
- Liangjie Du,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Jianjun Li
Affiliations
- Chunjia Zhang
- School of Rehabilitation, Capital Medical University, Beijing, China
- Chunjia Zhang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Yan Li
- Institute of Rehabilitation medicine, China Rehabilitation Research Center, Beijing, China
- Yan Yu
- Institute of Rehabilitation medicine, China Rehabilitation Research Center, Beijing, China
- Zehui Li
- School of Rehabilitation, Capital Medical University, Beijing, China
- Zehui Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Xin Xu
- School of Rehabilitation, Capital Medical University, Beijing, China
- Xin Xu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Zuliyaer Talifu
- School of Population Medicine and Public Health, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China
- Wubo Liu
- School of Rehabilitation, Capital Medical University, Beijing, China
- Wubo Liu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Wubo Liu
- Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Degang Yang
- School of Rehabilitation, Capital Medical University, Beijing, China
- Degang Yang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Feng Gao
- School of Rehabilitation, Capital Medical University, Beijing, China
- Feng Gao
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Song Wei
- School of Rehabilitation, Capital Medical University, Beijing, China
- Song Wei
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Liang Zhang
- School of Rehabilitation, Capital Medical University, Beijing, China
- Liang Zhang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Han Gong
- School of Rehabilitation, Capital Medical University, Beijing, China
- Han Gong
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Run Peng
- School of Rehabilitation, Capital Medical University, Beijing, China
- Run Peng
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Liangjie Du
- School of Rehabilitation, Capital Medical University, Beijing, China
- Liangjie Du
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jianjun Li
- School of Rehabilitation, Capital Medical University, Beijing, China
- Jianjun Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jianjun Li
- Institute of Rehabilitation medicine, China Rehabilitation Research Center, Beijing, China
- Jianjun Li
- Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1334828
- Journal volume & issue
-
Vol. 15
Abstract
Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal cord injury, inflammation plays a critical role; however, excessive inflammation can exacerbate pain. Regulatory T cells (Treg cells) have a crucial function in regulating inflammation and alleviating neuropathic pain. Treg cells release suppressor cytokines and modulate the function of other immune cells to suppress the inflammatory response. Simultaneously, inflammation impedes Treg cell activity, further intensifying neuropathic pain. Therefore, suppressing the inflammatory response while enhancing Treg cell regulatory function may provide novel therapeutic avenues for treating neuropathic pain resulting from spinal cord injury. This review comprehensively describes the mechanisms underlying the inflammatory response and Treg cell regulation subsequent to spinal cord injury, with a specific focus on exploring the potential mechanisms through which Treg cells regulate neuropathic pain following spinal cord injury. The insights gained from this review aim to provide new concepts and a rationale for the therapeutic prospects and direction of cell therapy in spinal cord injury-related conditions.
Keywords
