Seropositivity of Anti-Toxoplasma gondii IgG among type 2 diabetes mellitus patients

Abstract

Introduction. An estimated one-third of people worldwide are thought to be affected by toxoplasmosis, a common tropical disease with a wide geographic spread. The most common form of DM, namely type 2 diabetes arises from a combination of insulin resistance and inadequate compensatory insulin secretion. Methods. A case-control study was conducted from November 2022 to January 2023 from type 2 diabetic patients who attended outpatient clinics. Overall 96 patients who diabetes patients were screened for T. gondii seroprevalence. Results. By the ELISA method, the IgG antibodies in those were 90.63% and compared with a control group which the positive for T. gondii IgG antibodies 28%. The seropositivity of T. gondii IgG revealed that the patients living in urban areas were slightly higher than those in rural areas 58.3%, and 32.3%. The results showed that diabetic patients >60 years old had the highest rate of seropositive T. gondii infections (40.23%), while those ≤30 years old had the lowest rate (4.60%) with the mean of T2DM patients is 7.15 ± 1.94. Conclusion The current study revealed a high prevalence of T. gondii IgG among T2DM patients. The rate of seropositivity for T. gondii among patients living in the urban areas was slightly higher than in those in rural areas. The objective of the research was to ascertain whether T. gondii seropositivity and type 2 diabetes might be related.

Keywords

• toxoplasma gondii
• toxoplasmosis
• t2dm
• igg
• seropositivity