Nature Communications (Jul 2021)
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
- Ariella Zehender,
- Yi-Nan Li,
- Neng-Yu Lin,
- Adrian Stefanica,
- Julian Nüchel,
- Chih-Wei Chen,
- Hsiao-Han Hsu,
- Honglin Zhu,
- Xiao Ding,
- Jingang Huang,
- Lichong Shen,
- Andrea-Hermina Györfi,
- Alina Soare,
- Simon Rauber,
- Christina Bergmann,
- Andreas Ramming,
- Markus Plomann,
- Beate Eckes,
- Georg Schett,
- Jörg H. W. Distler
Affiliations
- Ariella Zehender
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Yi-Nan Li
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Neng-Yu Lin
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Adrian Stefanica
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Julian Nüchel
- Center for Biochemistry, University of Cologne, Faculty of Medicine
- Chih-Wei Chen
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Hsiao-Han Hsu
- Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University
- Honglin Zhu
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Xiao Ding
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Jingang Huang
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Lichong Shen
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Andrea-Hermina Györfi
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Alina Soare
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Simon Rauber
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Christina Bergmann
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Andreas Ramming
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Markus Plomann
- Center for Biochemistry, University of Cologne, Faculty of Medicine
- Beate Eckes
- Translational Matrix Biology, University of Cologne, Faculty of Medicine
- Georg Schett
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- Jörg H. W. Distler
- Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen
- DOI
- https://doi.org/10.1038/s41467-021-24601-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.
