Nature Communications (Jul 2020)
The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
- J. Allen Bennett,
- Michael A. Mastrangelo,
- Sara K. Ture,
- Charles O. Smith,
- Shannon G. Loelius,
- Rachel A. Berg,
- Xu Shi,
- Ryan M. Burke,
- Sherry L. Spinelli,
- Scott J. Cameron,
- Thomas E. Carey,
- Paul S. Brookes,
- Robert E. Gerszten,
- Maria Sabater-Lleal,
- Paul S. de Vries,
- Jennifer E. Huffman,
- Nicholas L. Smith,
- Craig N. Morrell,
- Charles J. Lowenstein
Affiliations
- J. Allen Bennett
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Michael A. Mastrangelo
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Sara K. Ture
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Charles O. Smith
- Department of Pharmacology and Physiology, University of Rochester Medical Center
- Shannon G. Loelius
- Department of Microbiology and Immunology, University of Rochester Medical Center
- Rachel A. Berg
- Department of Pathology and Laboratory Medicine, University of Rochester Medical Center
- Xu Shi
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center
- Ryan M. Burke
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Sherry L. Spinelli
- Department of Pathology and Laboratory Medicine, University of Rochester Medical Center
- Scott J. Cameron
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Thomas E. Carey
- Department of Otolaryngology-Head and Neck Surgery, University of Michigan
- Paul S. Brookes
- Department of Pharmacology and Physiology, University of Rochester Medical Center
- Robert E. Gerszten
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center
- Maria Sabater-Lleal
- Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Jennifer E. Huffman
- Center for Population Genomics, MAVERIC, VA Boston Healthcare System
- Nicholas L. Smith
- Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington
- Craig N. Morrell
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- Charles J. Lowenstein
- Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-17254-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.
