The Role of EMT-Related lncRNAs in Ovarian Cancer

Dimitra Ioanna Lampropoulou; Marios Papadimitriou; Christos Papadimitriou; Dimitrios Filippou; Georgia Kourlaba; Gerasimos Aravantinos; Maria Gazouli

doi:10.3390/ijms241210079

International Journal of Molecular Sciences (Jun 2023)

The Role of EMT-Related lncRNAs in Ovarian Cancer

Dimitra Ioanna Lampropoulou,
Marios Papadimitriou,
Christos Papadimitriou,
Dimitrios Filippou,
Georgia Kourlaba,
Gerasimos Aravantinos,
Maria Gazouli

Affiliations

Dimitra Ioanna Lampropoulou: ECONCARE LP, Health Research & Consulting, 11528 Athens, Greece
Marios Papadimitriou: Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
Christos Papadimitriou: Second Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Dimitrios Filippou: Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Georgia Kourlaba: Department of Nursing, University of Peloponnese, 22100 Tripoli, Greece
Gerasimos Aravantinos: Euroclinic, Athanasiadou 7-9, 11521 Athens, Greece
Maria Gazouli: Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

DOI: https://doi.org/10.3390/ijms241210079
Journal volume & issue: Vol. 24, no. 12
p. 10079

Abstract

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Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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