Frontiers in Cell and Developmental Biology (Jun 2021)

Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma

  • Yue Wu,
  • Yue Wu,
  • Xi Zhang,
  • Xian Wei,
  • Xian Wei,
  • Huan Feng,
  • Huan Feng,
  • Bintao Hu,
  • Bintao Hu,
  • Zhiyao Deng,
  • Zhiyao Deng,
  • Bo Liu,
  • Yang Luan,
  • Yang Luan,
  • Yajun Ruan,
  • Yajun Ruan,
  • Xiaming Liu,
  • Xiaming Liu,
  • Zhuo Liu,
  • Zhuo Liu,
  • Jihong Liu,
  • Jihong Liu,
  • Tao Wang,
  • Tao Wang

DOI
https://doi.org/10.3389/fcell.2021.684643
Journal volume & issue
Vol. 9

Abstract

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Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression. However, the molecular characteristics and prognostic value of ubiquitin in ccRCC have not been systematically reported. In our study, 204 differentially expressed ubiquitin related genes (URGs) were identified from The Cancer Genome Atlas (TCGA) cohort, including 141 up-regulated and 63 down-regulated URGs. A total of seven prognostic related URGs (CDCA3, CHFR, CORO6, RNF175, TRIM72, VAV3, and WDR72) were identified by Cox regression analysis of differential URGs and used to construct a prognostic signature. Kaplan-Meier analysis confirmed that high-risk patients had a worse prognosis (P = 1.11e-16), and the predicted area under the receiver operating characteristic (ROC) curves were 0.735 at 1 year, 0.702 at 3 years, and 0.744 at 5 years, showing good prediction accuracy. Stratified analysis showed that the URGs-based prognostic signature could be used to evaluate tumor progression in ccRCC. Further analysis confirmed that the signature is an independent prognostic factor related to the prognosis of ccRCC patients, which may help to reveal the molecular mechanism of ccRCC and provide potential diagnostic and prognostic markers for ccRCC.

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