ROLE OF CYTOCHROME P450 AND ITS ISOFORMS IN THE PHARMACOTHERAPY OF INFLAMMATORY DISEASES OF THE UPPER GASTROINTESTINAL TRACT IN CHILDREN

Abstract

The concept of personalization apply to pharmaceuticals, which is considered a universal means of treatment of specific diseases. But over time, it becomes clear that the response of the patients with the same disease at the same drug differs depending on genotype of the patient and other factors, so that there may be considerable variation in the efficacy and safety of the drug used to treat certain diseases. This is due to various factors, but chief among them are the peculiarities of the cytochrome P450 system, which plays an important role in maintaining the homeostasis of the chemical under physiological and pathological conditions of the internal environment.

Keywords

• cytochrome p450
• gene polymorphism
• metabolizer
• personalized medicine