Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant

Jiale Liu; Minjie Luo; Siyuan Lv; Shaohua Tao; Zhu Wu; Lihua Yu; Danna Lin; Lulu Huang; Li Wu; Xu Liao; Juan Zi; Xiaorong Lai; Yuting Yuan; Wangming Zhang; Lihua Yang

doi:10.3389/fendo.2022.865913

Frontiers in Endocrinology (Jul 2022)

Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant

Jiale Liu,
Minjie Luo,
Siyuan Lv,
Shaohua Tao,
Zhu Wu,
Lihua Yu,
Danna Lin,
Lulu Huang,
Li Wu,
Xu Liao,
Juan Zi,
Xiaorong Lai,
Yuting Yuan,
Wangming Zhang,
Lihua Yang

Affiliations

Jiale Liu: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Minjie Luo: Department of Pediatric Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Siyuan Lv: Department of Pediatric Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Shaohua Tao: Department of Pediatric Intensive Care Unit, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Zhu Wu: Department of Pediatric Intensive Care Unit, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Lihua Yu: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Danna Lin: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Lulu Huang: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Li Wu: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Xu Liao: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Juan Zi: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Xiaorong Lai: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Yuting Yuan: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Wangming Zhang: Department of Pediatric Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Lihua Yang: Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fendo.2022.865913
Journal volume & issue: Vol. 13

Abstract

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In this study, atypical choroid plexus papilloma was treated with high-dose rapamycin for 17 days preoperatively in an infant. Rapamycin significantly reduced the blood supply to the tumor while reducing the tumor volume, and most of the tumor was resected successfully. However, the infant developed hyperglycemia related to the rapamycin dose, which was effectively controlled by adjusting the dose and applying insulin.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

About the journal

Abstract

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