Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery
Esra Altun,
Esra Yuca,
Nazmi Ekren,
Deepak M. Kalaskar,
Denisa Ficai,
Georgiana Dolete,
Anton Ficai,
Oguzhan Gunduz
Affiliations
Esra Altun
Centre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey
Esra Yuca
Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Davutpasa Campus, Yildiz Technical University, Istanbul 34220, Turkey
Nazmi Ekren
Centre for Nanotechnology & Biomaterials Research, Department of Electrical-Electronics Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey
Deepak M. Kalaskar
UCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
Denisa Ficai
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
Georgiana Dolete
National Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
Anton Ficai
National Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
Oguzhan Gunduz
Centre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey
This study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demonstrated facilitated drug loading and encapsulation efficiency of drugs along with extended drug release profiles. Release curves were also subjected to model fitting, and it was found that drug release was optimally adapted to the Higuchi square root model for each drug. They performed a time-dependent and diffusion-controlled release from the patches and followed Fick’s diffusion law by the Korsmeyer–Peppas energy law equation. Moreover, produced patches demonstrated excellent antimicrobial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains, so they could be helpful in the treatment of chronic infectious lesions during wound closures. As different tests have confirmed, various types of antibiotics could be loaded and successfully released regardless of their types from produced BC/PCL patches. This study could breathe life into the production of antibiotic patches for local transdermal applications in wound dressing studies and improve the quality of life of patients.