Analysis of Gene-Environment Interactions Related to Developmental Disorders

Yuhei Nishimura; Kenji Kurosawa; Kenji Kurosawa

doi:10.3389/fphar.2022.863664

Frontiers in Pharmacology (Mar 2022)

Analysis of Gene-Environment Interactions Related to Developmental Disorders

Yuhei Nishimura,
Kenji Kurosawa,
Kenji Kurosawa

Affiliations

Yuhei Nishimura: Department of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Japan
Kenji Kurosawa: Division of Medical Genetics, Kanagawa Children’s Medical Center, Yokohama, Japan
Kenji Kurosawa: Department of Clinical Dysmorphology, Mie University Graduate School of Medicine, Tsu, Japan

DOI: https://doi.org/10.3389/fphar.2022.863664
Journal volume & issue: Vol. 13

Abstract

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Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G × E) is involved in the etiology of DDs. There are two major approaches to analyze the interaction: genome-wide and candidate gene-based approaches. In this mini-review, we demonstrate how these approaches can be applied to reveal the G × E related to DDs focusing on zebrafish and mouse models. We also discuss novel approaches to analyze the G × E associated with DDs.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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