Nature Communications (Feb 2022)

Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity

  • Karolina Piekarska,
  • Zuzanna Urban-Wójciuk,
  • Małgorzta Kurkowiak,
  • Iwona Pelikant-Małecka,
  • Adriana Schumacher,
  • Justyna Sakowska,
  • Jan Henryk Spodnik,
  • Łukasz Arcimowicz,
  • Hanna Zielińska,
  • Bogusław Tymoniuk,
  • Alicja Renkielska,
  • Janusz Siebert,
  • Ewa Słomińska,
  • Piotr Trzonkowski,
  • Ted Hupp,
  • Natalia Maria Marek-Trzonkowska

DOI
https://doi.org/10.1038/s41467-022-28338-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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Regulatory T (Treg) cells and mesenchymal stem cells (MSCs) are both cell populations capable of immune tolerance induction. Here the authors show that the transfer of mitochondria from mesenchymal stem cells to allogeneic Treg cells in an HLA-dependent manner results in enhanced immunosuppressive functions of Treg cells.