An actualized screening of schizophrenia-associated genes

Abstract

Abstract Background Schizophrenia is a psychotic disorder that impacts around 0.5% to 1.2% of the world's population. It has been well established that heredity plays an essential role in the causation of schizophrenia, with genetic heritability of up to 80%. A several new schizophrenia susceptibility genes were identified at the start of the twenty-first century. The aim of this systematic review will be to explore the association between single nucleotide polymorphisms (SNPs) and schizophrenia risk in people all over the world. Methods This systematic review collected available data on genetic variants associated with schizophrenia in worldwide populations. A PubMed and Science Direct search was investigated to identify all studies published until December 2020 on genetic susceptibility to schizophrenia in various populations, excluding family studies, transversal studies, cohort studies, experimental studies, and descriptive studies; those that demonstrate an association between repeat polymorphism (CNV, VNTR, etc.). All researches on genetic predispositions of schizophrenia and accepting the predetermined inclusion criteria were included in this systematic review. Findings Thirty-six studies focused on the schizophrenia-associated genes were retained in which a total of 44 polymorphisms among 26 susceptibility genes to schizophrenia have been associated in the world populations. Conclusion Despite the few number of studies published about genetic of schizophrenia, some genetic variations have been consistently correlated to schizophrenia, particularly in China, as this analysis shows. Further data, especially from genome-wide association studies, might contribute in the development of a reference for schizophrenia genetic susceptibility markers.

Keywords

• Genetics
• Schizophrenia
• Systematic review
• Genes
• Polymorphisms
• Psychiatry