Variability and stability of large-scale cortical oscillation patterns

Abstract

Individual differences in brain organization exist at many spatiotemporal scales and underlie the diversity of human thought and behavior. Oscillatory neural activity is crucial for these processes, but how such rhythms are expressed across the cortex within and across individuals is poorly understood. We conducted a systematic characterization of brain-wide activity across frequency bands and oscillatory features during rest and task execution. We found that oscillatory profiles exhibit sizable group-level similarities, indicating the presence of common templates of oscillatory organization. Nonetheless, well-defined subject-specific network profiles were discernible beyond the structure shared across individuals. These individualized patterns were sufficiently stable to recognize individuals several months later. Moreover, network structure of rhythmic activity varied considerably across distinct oscillatory frequencies and features, indicating the existence of several parallel information processing streams embedded in distributed electrophysiological activity. These findings suggest that network similarity analyses may be useful for understanding the role of large-scale brain oscillations in physiology and behavior. Neural oscillations are critical for the human brain’s ability to optimally respond to complex environmental input. However, relatively little is known about the network properties of these oscillatory rhythms. We used electroencephalography (EEG) to analyze large-scale brain wave patterns, focusing on multiple frequency bands and several key features of oscillatory communication. We show that networks defined in this manner are, in fact, distinct, suggesting that EEG activity encompasses multiple, parallel information processing streams. Remarkably, the same networks can be used to uniquely identify individuals over a period of approximately half a year, thus serving as neural fingerprints. These findings indicate that investigating oscillatory dynamics from a network perspective holds considerable promise as a tool to understand human cognition and behavior.

Keywords

• EEG
• Oscillations
• Networks
• Functional connectivity
• Individual differences