Somatic nuclear blebbing in <i>Caenorhabditis elegans</i> is not a feature of organismal aging but a potential indicator of germline proliferation in early adulthood

Abstract

AbstractAbnormal nuclear morphology is suggested to be a hallmark of aging and one such abnormality is nuclear blebbing. However, little is known about whether and how nuclear blebbing participates in animal aging, and what regulates it. In this study, we show that the frequency of nuclear blebbing in the hypodermis increases during aging in wild-type C. elegansC. elegans