Nature Communications (May 2021)

Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE

  • Christa Caggiano,
  • Barbara Celona,
  • Fleur Garton,
  • Joel Mefford,
  • Brian L. Black,
  • Robert Henderson,
  • Catherine Lomen-Hoerth,
  • Andrew Dahl,
  • Noah Zaitlen

DOI
https://doi.org/10.1038/s41467-021-22901-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Tissue damage and turnover lead to the release of DNA in the blood and can be used to monitor changes in tissue state. Here, the authors developed a tool to accurately estimate the proportion of cell types contributing to cell-free DNA in the blood, with an application to pregnant women and ALS patients.