Nature Communications (Nov 2022)
Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
- Wen Su,
- Sijin Wu,
- Yongliang Yang,
- Yanlin Guo,
- Haibo Zhang,
- Jie Su,
- Lei Chen,
- Zhuo Mao,
- Rongfeng Lan,
- Rong Cao,
- Chunjiong Wang,
- Hu Xu,
- Cong Zhang,
- Sha Li,
- Min Gao,
- Xiaocong Chen,
- Zhiyou Zheng,
- Bing Wang,
- Yi’ao Liu,
- Zuojun Liu,
- Zimei Wang,
- Baohua Liu,
- Xinmin Fan,
- Xiaoyan Zhang,
- Youfei Guan
Affiliations
- Wen Su
- Department of Pathophysiology, Shenzhen University
- Sijin Wu
- State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Yongliang Yang
- Laboratoy of Innovative Drug Discovery, School of Bioengineering, Dalian University of Technology
- Yanlin Guo
- Health Science Center, East China Normal University
- Haibo Zhang
- Advanced Institute for Medical Sciences, Dalian Medical University
- Jie Su
- Department of Pathophysiology, Shenzhen University
- Lei Chen
- Department of Pathophysiology, Shenzhen University
- Zhuo Mao
- Shenzhen University Health Science Center, Shenzhen University
- Rongfeng Lan
- Shenzhen University Health Science Center, Shenzhen University
- Rong Cao
- Department of Nephrology, The First Affiliated Hospital of Shenzhen University
- Chunjiong Wang
- Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University
- Hu Xu
- Advanced Institute for Medical Sciences, Dalian Medical University
- Cong Zhang
- Advanced Institute for Medical Sciences, Dalian Medical University
- Sha Li
- Medical College, Hebei University of Engineering
- Min Gao
- Shenzhen University Health Science Center, Shenzhen University
- Xiaocong Chen
- Shenzhen University Health Science Center, Shenzhen University
- Zhiyou Zheng
- Shenzhen University Health Science Center, Shenzhen University
- Bing Wang
- Advanced Institute for Medical Sciences, Dalian Medical University
- Yi’ao Liu
- Shenzhen University Health Science Center, Shenzhen University
- Zuojun Liu
- Shenzhen University Health Science Center, Shenzhen University
- Zimei Wang
- Shenzhen University Health Science Center, Shenzhen University
- Baohua Liu
- Shenzhen University Health Science Center, Shenzhen University
- Xinmin Fan
- Department of Pathophysiology, Shenzhen University
- Xiaoyan Zhang
- Health Science Center, East China Normal University
- Youfei Guan
- Advanced Institute for Medical Sciences, Dalian Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34299-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
A truncating variant of 17β-hydroxysteroid dehydrogenase-13 (17β-HSD13), a lipid droplet -associated protein, associates with lower risk of chronic liver disease. Here the authors identify a phosphorylation site in 17β-HSD13 which promotes lipolysis, and report that a knock-in mouse with a 17β-HSD13 mutant defective for phosphorylation is more susceptible to nonalcoholic steatohepatitis.
