Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

Sin Ki Fung; Taotao Zou; Bei Cao; Tianfeng Chen; Wai-Pong To; Chen Yang; Chun-Nam Lok; Chi-Ming Che

doi:10.1038/ncomms10655

Nature Communications (Feb 2016)

Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

Sin Ki Fung,
Taotao Zou,
Bei Cao,
Tianfeng Chen,
Wai-Pong To,
Chen Yang,
Chun-Nam Lok,
Chi-Ming Che

Affiliations

Sin Ki Fung: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Taotao Zou: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Bei Cao: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Tianfeng Chen: Department of Chemistry, Jinan University
Wai-Pong To: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Chen Yang: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Chun-Nam Lok: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong
Chi-Ming Che: and Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre, The University of Hong Kong

DOI: https://doi.org/10.1038/ncomms10655
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

Read online

DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells. Here, the authors present luminescent platinum based probes capable of preferentially binding to mismatched and abasic DNA, and reporting this by a significant luminescence enhancement

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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