Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report

Bowen Chang; Bowen Chang; Bowen Chang; Jiaming Mei; Jiaming Mei; Jiaming Mei; Chi Xiong; Chi Xiong; Chi Xiong; Peng Chen; Peng Chen; Peng Chen; Manli Jiang; Manli Jiang; Manli Jiang; Chaoshi Niu; Chaoshi Niu; Chaoshi Niu

doi:10.3389/fnins.2021.782046

Frontiers in Neuroscience (Nov 2021)

Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report

Bowen Chang,
Bowen Chang,
Bowen Chang,
Jiaming Mei,
Jiaming Mei,
Jiaming Mei,
Chi Xiong,
Chi Xiong,
Chi Xiong,
Peng Chen,
Peng Chen,
Peng Chen,
Manli Jiang,
Manli Jiang,
Manli Jiang,
Chaoshi Niu,
Chaoshi Niu,
Chaoshi Niu

Affiliations

Bowen Chang: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Bowen Chang: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Bowen Chang: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China
Jiaming Mei: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Jiaming Mei: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Jiaming Mei: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China
Chi Xiong: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Chi Xiong: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Chi Xiong: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China
Peng Chen: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Peng Chen: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Peng Chen: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China
Manli Jiang: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Manli Jiang: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Manli Jiang: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China
Chaoshi Niu: Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
Chaoshi Niu: Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China
Chaoshi Niu: Anhui Key Laboratory of Brain Function and Brain Disease, First Affiliated Hospital of University of Science and Technology of China, Hefei, China

DOI: https://doi.org/10.3389/fnins.2021.782046
Journal volume & issue: Vol. 15

Abstract

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Background: Main motor characteristics in Parkinson's disease (PD) include bradykinesia, rigidity, and tremors. With the development of neuromodulation techniques, it has become possible to use deep brain stimulation (DBS) to control the symptoms of PD. However, since the subthalamic nucleus(STN) and globus pallidus interna (GPi) DBS have their own advantages and disadvantages, it is difficult to control symptoms of the patients. It is essential to find new stimulation methods.Case Presentation: A 33-year-old male PD patient with onset at the age of 12 years. The onset of the disease is presented with bradykinesia and progressively developed severe choreic dyskinesia with the use of medications. We then performed a thorough evaluation of the patient and decided to perform bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS (bSGC-DBS) implantation, and after 2 years of follow-up the patient's bradykinesia and dyskinesia symptoms and quality of life improved significantly.Conclusions: This is the first case of bSCG-DBS in a PD patient with refractory dyskinesia, and the first report of encouraging results from this clinical condition. This important finding explores multi-electrode and multi-target stimulation for the treatment of dystonia disorders.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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