Nature Communications (Jun 2017)
Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
- Junchao Cai,
- Lishan Fang,
- Yongbo Huang,
- Rong Li,
- Xiaonan Xu,
- Zhihuang Hu,
- Le Zhang,
- Yi Yang,
- Xun Zhu,
- Heng Zhang,
- Jueheng Wu,
- Yan Huang,
- Jun Li,
- Musheng Zeng,
- Erwei Song,
- Yukai He,
- Li Zhang,
- Mengfeng Li
Affiliations
- Junchao Cai
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Lishan Fang
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Yongbo Huang
- State Key Laboratory of Respiratory Diseases and Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University
- Rong Li
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Xiaonan Xu
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Zhihuang Hu
- Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center
- Le Zhang
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Yi Yang
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Xun Zhu
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- Heng Zhang
- Neurosurgery Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University
- Jueheng Wu
- Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education
- Yan Huang
- Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center
- Jun Li
- Department of Biochemistry, Sun Yat-sen University Zhongshan School of Medicine
- Musheng Zeng
- Department of Experimental Research, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center
- Erwei Song
- Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Yukai He
- Department of Medicine and Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University
- Li Zhang
- Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center
- Mengfeng Li
- Department of Microbiology, Sun Yat-sen University Zhongshan School of Medicine
- DOI
- https://doi.org/10.1038/ncomms15870
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.
