Hepatosplenic Gamma Delta T cell Lymphoma in a Young Male with Visceral Leishmaniasis

Abstract

Hepatosplenic gamma delta T-cell lymphoma (HSTCL) is a rare peripheral T-cell lymphoma of cytotoxic T-cell origin with an aggressive clinical course. It is characterized by hepatosplenomegaly without significant lymphadenopathy, with clinically significant cytopenias. Chronic immunosuppression has been proposed as a possible pathogenetic mechanism in HSTCL. No association of HSTCL with visceral leishmaniasis has been described in the past. We describe a case of an adolescent male patient with HSTCL with leukemic presentation, who was diagnosed to have visceral leishmaniasis, nine months prior to presentation at our centre.

Keywords

• Leishmaniasis
• Hepatosplenic gamma delta T cell lymphoma
• leukemic presentation
• immunophenotyping