Nature Communications (Mar 2016)
The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
- Mariam H. Orme,
- Gianmaria Liccardi,
- Nina Moderau,
- Rebecca Feltham,
- Sidonie Wicky-John,
- Tencho Tenev,
- Lior Aram,
- Rebecca Wilson,
- Katiuscia Bianchi,
- Otto Morris,
- Celia Monteiro Domingues,
- David Robertson,
- Meghana Tare,
- Alexander Wepf,
- David Williams,
- Andreas Bergmann,
- Matthias Gstaiger,
- Eli Arama,
- Paulo S. Ribeiro,
- Pascal Meier
Affiliations
- Mariam H. Orme
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Gianmaria Liccardi
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Nina Moderau
- John Vane Science Centre, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
- Rebecca Feltham
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Sidonie Wicky-John
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Tencho Tenev
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Lior Aram
- Department of Molecular Genetics, Weizmann Institute of Science
- Rebecca Wilson
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Katiuscia Bianchi
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Otto Morris
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Celia Monteiro Domingues
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- David Robertson
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- Meghana Tare
- University of Massachusetts Medical School
- Alexander Wepf
- ETH, Institute for Molecular Systems Biology
- David Williams
- UCLA David Geffen School of Medicine
- Andreas Bergmann
- University of Massachusetts Medical School
- Matthias Gstaiger
- ETH, Institute for Molecular Systems Biology
- Eli Arama
- Department of Molecular Genetics, Weizmann Institute of Science
- Paulo S. Ribeiro
- John Vane Science Centre, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
- Pascal Meier
- Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research
- DOI
- https://doi.org/10.1038/ncomms10972
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.
