Nature Communications (Jun 2020)
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
- Nellie Y. Loh,
- James E. N. Minchin,
- Katherine E. Pinnick,
- Manu Verma,
- Marijana Todorčević,
- Nathan Denton,
- Julia El-Sayed Moustafa,
- John P. Kemp,
- Celia L. Gregson,
- David M. Evans,
- Matt J. Neville,
- Kerrin S. Small,
- Mark I. McCarthy,
- Anubha Mahajan,
- John F. Rawls,
- Fredrik Karpe,
- Constantinos Christodoulides
Affiliations
- Nellie Y. Loh
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- James E. N. Minchin
- Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University
- Katherine E. Pinnick
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Manu Verma
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Marijana Todorčević
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Nathan Denton
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Julia El-Sayed Moustafa
- Department of Twin Research and Genetic Epidemiology, King’s College
- John P. Kemp
- The University of Queensland Diamantina Institute, University of Queensland
- Celia L. Gregson
- Musculoskeletal Research Unit, Translational Health Sciences, University of Bristol, Southmead Hospital
- David M. Evans
- The University of Queensland Diamantina Institute, University of Queensland
- Matt J. Neville
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Kerrin S. Small
- Department of Twin Research and Genetic Epidemiology, King’s College
- Mark I. McCarthy
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Anubha Mahajan
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- John F. Rawls
- Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University
- Fredrik Karpe
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Constantinos Christodoulides
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-020-16592-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafish
