Microorganisms (Mar 2022)
<i>Acinetobacter baumannii</i> Isolates from COVID-19 Patients in a Hospital Intensive Care Unit: Molecular Typing and Risk Factors
- Mariateresa Ceparano,
- Valentina Baccolini,
- Giuseppe Migliara,
- Claudia Isonne,
- Erika Renzi,
- Daniela Tufi,
- Corrado De Vito,
- Maria De Giusti,
- Maria Trancassini,
- Francesco Alessandri,
- Giancarlo Ceccarelli,
- Francesco Pugliese,
- Paolo Villari,
- Maria Angiulli,
- Stefania Battellito,
- Arianna Bellini,
- Andrea Bongiovanni,
- Lucilla Caivano,
- Marta Castellani,
- Monica Coletti,
- Alessia Cottarelli,
- Ludovica D’Agostino,
- Andrea De Giorgi,
- Chiara De Marchi,
- Irma Germani,
- Dara Giannini,
- Elisa Mazzeo,
- Shadi Orlandi,
- Matteo Piattoli,
- Eleonora Ricci,
- Leonardo Maria Siena,
- Alessandro Territo,
- Gianluca Vrenna,
- Stefano Zanni,
- Carolina Marzuillo
Affiliations
- Mariateresa Ceparano
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Valentina Baccolini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Giuseppe Migliara
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Claudia Isonne
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Erika Renzi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Daniela Tufi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Corrado De Vito
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Maria De Giusti
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Maria Trancassini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Francesco Alessandri
- Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy
- Giancarlo Ceccarelli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Francesco Pugliese
- Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy
- Paolo Villari
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Maria Angiulli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Stefania Battellito
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Arianna Bellini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Andrea Bongiovanni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Lucilla Caivano
- Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy
- Marta Castellani
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Monica Coletti
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Alessia Cottarelli
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Ludovica D’Agostino
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Andrea De Giorgi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Chiara De Marchi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Irma Germani
- Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy
- Dara Giannini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Elisa Mazzeo
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Shadi Orlandi
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Matteo Piattoli
- Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy
- Eleonora Ricci
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Leonardo Maria Siena
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Alessandro Territo
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Gianluca Vrenna
- Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy
- Stefano Zanni
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- Carolina Marzuillo
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
- DOI
- https://doi.org/10.3390/microorganisms10040722
- Journal volume & issue
-
Vol. 10,
no. 4
p. 722
Abstract
Infections caused by Acinetobacter baumannii represent a major concern for intensive care unit (ICU) patients. However, the epidemiology of these infections among COVID-19 patients has not been fully explored. The aims of this study were (i) to characterize the clonal spread of A. baumannii among COVID-19 patients admitted to the ICU of the Umberto I hospital of Rome during the first year of the pandemic and (ii) to identify risk factors for its acquisition. Isolates were analysed by pulsed-field gel electrophoresis, and a multivariable regression model was constructed. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated. Overall, 193 patients were included, and 102 strains were analysed. All isolates had highly antibiotic-resistant profiles and derived from two genotypes. The cumulative incidence of A. baumannii acquisition (colonization or infection) was 36.8%. Patients with A. baumannii had higher mortality and length of stay. Multivariable analysis showed that previous carbapenem use was the only risk factor associated with A. baumannii acquisition (aOR: 4.15, 95% CI: 1.78–9.64). We documented substantial A. baumannii infections and colonization and high levels of clonal transmission. Given the limited treatment options, effective prevention and containment strategies to limit the spread of A. baumannii should be implemented.
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