Circulating miRNome profiling data in Behçet's syndrome
Giacomo Bagni,
Giacomo Emmi,
Elena Lastraioli,
Francesca Di Patti,
Elena Silvestri,
Angela Guerriero,
Serena Pillozzi,
Elena Niccolai,
Amedeo Amedei,
Lorenzo Emmi,
Domenico Prisco,
Annarosa Arcangeli
Affiliations
Giacomo Bagni
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Giacomo Emmi
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; SOD Interdisciplinary Internal Medicine-Behçet Center and Lupus Clinic–Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Elena Lastraioli
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Francesca Di Patti
Department of Physics, University of Florence, Sesto Fiorentino, Florence, Italy; Center for the Study of Complex Dynamics (CSDC), Sesto Fiorentino, Florence, Italy
Elena Silvestri
SOD Interdisciplinary Internal Medicine-Behçet Center and Lupus Clinic–Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Angela Guerriero
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Serena Pillozzi
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Elena Niccolai
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Amedeo Amedei
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; SOD Interdisciplinary Internal Medicine-Behçet Center and Lupus Clinic–Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Lorenzo Emmi
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy
Domenico Prisco
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Annarosa Arcangeli
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Center for the Study of Complex Dynamics (CSDC), Sesto Fiorentino, Florence, Italy; Corresponding author at: Department of Experimental and Clinical Medicine, University of Florence, Florence Italy.
We conducted a screening analysis to assess the presence of a characteristic extracellular circulating microRNAs (ci-miRNAs) profile in Behçet's syndrome (BS).Total RNA was extracted from platelets-free plasma (PFP) samples obtained from 16 BS patients and 18 healthy controls. Ci-miRNAs profiling was conducted by using dedicated Agilent microarray hybridization and data extraction technology. Statistical analysis of data extracted from microarray scanning revealed the deregulation of 36 ci-miRNAs, which turned out be differentially expressed between BS patients and healthy controls. Detailed experimental methods and data analysis were described here.The raw and normalized microarray data were deposited into Gene Expression Omnibus (GEO) under accession number GSE145191.
