Nature Communications (Feb 2017)

P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5

  • Francis Galaway,
  • Laura G. Drought,
  • Maria Fala,
  • Nadia Cross,
  • Alison C. Kemp,
  • Julian C. Rayner,
  • Gavin J. Wright

DOI
https://doi.org/10.1038/ncomms14333
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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The secretedPlasmodium falciparum protein RH5 is essential for invasion of erythrocytes and is a promising vaccine candidate. Here, Galaway et al. show that the N-terminal region of RH5 binds the GPI-anchored merozoite surface protein P113 and can elicit invasion-blocking antibodies.