piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair

Basudeb Das; Neha Jain; Bibekanand Mallick

doi:10.1038/s42003-021-02844-1

Communications Biology (Nov 2021)

piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair

Basudeb Das,
Neha Jain,
Bibekanand Mallick

Affiliations

Basudeb Das: RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology Rourkela
Neha Jain: RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology Rourkela
Bibekanand Mallick: RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology Rourkela

DOI: https://doi.org/10.1038/s42003-021-02844-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 18

Abstract

Read online

Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued apoptosis and anti-proliferative effects in parental HT1080 cells, as well as DNA damage by regulating RRM2 and CYP1A2.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal