Abstract Background Lung cancer remains a leading cause of cancer-related mortality, primarily because of the lack of effective diagnostic and therapeutic biomarkers. To address the issue of fragmented biomarker data across numerous publications, we have developed the Lung Cancer Biomarker Database (LCBD, http://lcbd.biomarkerdb.com ). Methods We comprehensively reviewed biomarker-related studies up to June 30, 2023, and extracted relevant biomarker information. The identified biomarkers were systematically annotated, including genes, proteins, GO terms, KEGG pathways, biomarker types, molecular types, developmental stages, discovery methods, sources, populations, and sample sizes. The LCBD online platform was developed to integrate lung cancer biomarker data, and provide search, browsing, and data download functions for researchers. To validate the data in the LCBD, we conducted three case studies comparing models with and without LCBD data. Results After deduplication and summarization, we collected 1,447 unique biomarkers that were systematically annotated. We then developed the LCBD specifically for use in lung cancer diagnosis. The validity of the biomarkers in the LCBD was confirmed using prognostic models, diagnostic models, and immune infiltration models. Conclusion The LCBD provides a centralized platform for lung cancer biomarkers, facilitating early screening and personalized treatment. This database is poised to become a valuable resource for lung cancer research and therapeutic strategies.
