Nature Communications (Nov 2017)

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

  • Michael H. Berry,
  • Amy Holt,
  • Joshua Levitz,
  • Johannes Broichhagen,
  • Benjamin M. Gaub,
  • Meike Visel,
  • Cherise Stanley,
  • Krishan Aghi,
  • Yang Joon Kim,
  • Kevin Cao,
  • Richard H. Kramer,
  • Dirk Trauner,
  • John Flannery,
  • Ehud Y. Isacoff

DOI
https://doi.org/10.1038/s41467-017-01990-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.