The effects of short-term creatine monohydrate supplementation on a single resistance exercise induced-indirect indicators some of cellular damage in male wrestler

Abstract

Purpose: Creatine monohydrate as one of the most widely consumed nutritional supplements to increaseathletic performance is widely popular among athletes. However, there are recent concerns about some ofthe adverse effects of short and long term use of creatine on health indices. Therefore this study wasconducted to identify the effect of creatine monohydrate loading on total serum cellular damage indiceschanges (Creatine Kinase & Lactate Dehydrogenase) following one session resistance exercise in malewrestler. Methods: Eighteen volunteer collegiate young male wrestlers (aged 21.11±1.13 years, fat12.67±1.84 %, and BMI 21.96±0.70 kg/m2) in a quasi-experimental, randomized and double-blind designwere allocated equally into supplement and placebo groups. After six consecutive days supplementation(300 mg.kg-1.day body weight creatine monohydrate or dextrose), all subjects were participated in asingle- session circle resistance exercise protocol (with 80 % 1-RM in 3 sets with 6 repetition) include sixstation participated. Changes in cellular damage indices were determined in three phases (before and afterthe supplement phase, 24 hours after the exercise protocol). Data were analyzed by repeated measureANOVA, Bonferroni and independent t test at α≤0.05. Results: The results show that the creatine loadinghas only significant effect on the basal total serum CK in supplement group (P0.05).Conclusion: According tonormal variation of total serum Creatine Kinase in the base case and due to the lack of effect of creatineon 24 hours indicators of cellular damage in male wrestler after the resistance exercise, definitivecomment in related creatine supplementation induced- cellular damage, more research is needed in thefurther.

Keywords

• creatine monohydrate
• resistance exercise
• creatine kinase
• lactate dehydrogenase