Quality of life and its influencing factors in patients with atrial fibrillation

Abstract

Objective To explore the quality of life and its influencing factors in patients with atrial fibrillation (AF). Methods The Chinese Atrial Fibrillation Effect on Quality-of-Life(AFEQT) questionnaire was used to investigate the quality of life in AF patients who had been treated in the Department of Cardiovascular Diseases of 2 tertiary Class A hospitals from June 2016 to March 2021. Multivariate logistic regression model was used to analyze the factors related to the quality of life in the patients. Results A total of 321 AF patients were investigated. The median of total score for quality of life was 79.86 (interquartile range: 70.25, 89.81) in the AF patients. Multivariate logistic regression analysis on different dimensions of quality of life found that smoking history, elevated thrombin time (TT), total protein and D-dimer levels were risk factors in the symptom dimension, while a history of thyroid dysfunction was a protective factor; risk factors in the daily activity dimension included advanced age (≥65 years), hypertension history, stroke history, history of warfarin use, and prolonged TT, while alcohol consumption may be protective factors; the patients with history of hypertension, warfarin and statin use, and elevated monocyte (MONO) count and prolonged prothrombin time (PT) had significantly lower scores in the dimension of treatment of worried, while an activated partial thromboplastin time ratio (APTT-ratio) was a protective factor in the treatment of the worry score; prolonged TT was a risk factor for decreased treatment satisfaction scores; a history of novel oral anticoagulants (NOACs) and elevated APTT-ratio were protective factors for decreased treatment satisfaction scores; risk factors for decreased overall quality of life scores included advanced age (≥75 years), history of stroke, warfarin and statin use, and D-dimer level, while alcohol consumption and higher neutrophil count were protective factors. Conclusion Advanced age (≥65 years), smoking history, warfarin and statin history, hypertension, stroke history, elevated MONO, TP, TT, PT, and D-dimer level affect quality of life in AF patients in different dimensions.

Keywords

• atrial fibrillation
• quality of life
• influencing factors
• quality of life for atrial fibrillation patients