Nature Communications (Aug 2019)
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response
- Yi Yang,
- Thea L. Willis,
- Robert W. Button,
- Conor J. Strang,
- Yuhua Fu,
- Xue Wen,
- Portia R. C. Grayson,
- Tracey Evans,
- Rebecca J. Sipthorpe,
- Sheridan L. Roberts,
- Bing Hu,
- Jianke Zhang,
- Boxun Lu,
- Shouqing Luo
Affiliations
- Yi Yang
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Thea L. Willis
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Robert W. Button
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Conor J. Strang
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Yuhua Fu
- State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University
- Xue Wen
- State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University
- Portia R. C. Grayson
- Peninsula Dental School, Faculty of Medicine and Dentistry, University of Plymouth
- Tracey Evans
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Rebecca J. Sipthorpe
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Sheridan L. Roberts
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- Bing Hu
- Peninsula Dental School, Faculty of Medicine and Dentistry, University of Plymouth
- Jianke Zhang
- Department of Microbiology and Immunology, Thomas Jefferson University
- Boxun Lu
- State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University
- Shouqing Luo
- Peninsula Medical School, Faculty of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth
- DOI
- https://doi.org/10.1038/s41467-019-11671-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
The autophagy protein p62 undergoes liquid-liquid phase separation but how this is regulated is unclear. Here, the authors report that the histone chaperone DAXX interacts with p62 in the cytoplasm to drive its phase separation.
