Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors

• Hiroaki Ikeda,
• Hideo Yagita,
• Hiroshi Mukae,
• Kiyoshi Yasui,
• Yosuke Dotsu,
• Naohisa Ogo,
• Yudai Sonoda,
• Hiroyuki Yamaguchi,
• Akira Asai,
• Daisuke Muraoka

Affiliations

Hiroaki Ikeda

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Hideo Yagita

Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

Hiroshi Mukae

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Kiyoshi Yasui

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Yosuke Dotsu

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Naohisa Ogo

Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Yudai Sonoda

Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Hiroyuki Yamaguchi

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Akira Asai

Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

Daisuke Muraoka

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan