Early warning triad for pulmonary microemboli in COVID-19 pneumonia: Pulmonary artery diameter, D-dimer and NT-proBNP

Abstract

In COVID-19 patients, thrombotic and fibrinolytic events due to hyperinflammation coexist. This causes enlargement of the pulmonary artery trunk, increased D-dimer and proBNP levels. We studied the correlation of PAD, D-dimer, and NT-proBNP levels. We saw that microemboli can be predicted by using this correlation. 908 patients treated due to Covid-19 were included in the study. The patients were divided into two groups as survivors and mortal and divided into 4 groups according to lung involvement. Demographic, laboratory, and CT data were obtained from the hospital data recording system. When comparing inflammatory parameters, D-Dimer, PAD, NT-proBNP levels, we detected a significant difference between groups. There was a positive correlation between D-dimer, PAD, and NT-proBNP levels. Lung involvement more than 50% significantly increased mortality. The diagnosis of PE in patients with COVID-19 has vital importance. Rapid, reliable, non-invasive, easily accessible and low-cost tests are important in diagnosis. We predict that PAD and concurrent D-dimer with NT-proBNP elevation will enable earlier detection of pulmonary microemboli, determine mortality and prognosis, and help to regulate anticoagulation treatments earlier. [Med-Science 2022; 11(2.000): 775-9]

Keywords

• covid-19
• pulmonary embolism
• pulmonary artery diameter
• d-dimer
• probnp