We propose a solution to the symmetric nonlinear Ψ-Caputo fractional integro differential equations involving non-instantaneous impulsive boundary conditions. We investigate the existence and uniqueness of the solution for the proposed problem. Banach contraction theorem is employed to prove the uniqueness results, while Krasnoselkii’s fixed point technique is used to prove the existence results. Additionally, an example is used to explain the results. In this manner, our results represent generalized versions of some recent interesting contributions.