Clinical and Translational Medicine (Sep 2020)
Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
- Fugui Yan,
- Wen Li,
- Wei‐jie Guan,
- Min Chen,
- Chen Qiu,
- Wei Tang,
- Xiansheng Liu,
- Xudong Xiang,
- Jing Li,
- Meiling Jin,
- Yuanrong Dai,
- Ping Chen,
- Xiaohong Wu,
- Zhongmin Qiu,
- Liang Dong,
- Limin Zhao,
- Xiaoping Lin,
- Changgui Wu,
- Bin Wu,
- Yalian Yuan,
- Fei Shi,
- Ting Zhang,
- Jun Zhou,
- Min Xie,
- Xiaoyu Fang,
- Hongliang Zhang,
- Bing Xiao,
- Mo Xian,
- Jian Wang,
- Zhangwei Qiu,
- Jie Lin,
- Bingbing Ji,
- Yong Zhou,
- Yu Li,
- Chunhong Liu,
- Yiping Chen,
- Yiming Zeng,
- Lingli Liu,
- Wen Hua,
- Huaqiong Huang,
- Jiesen Zhou,
- Yue Hu,
- Luanqing Che,
- Songmin Ying,
- Zhihua Chen,
- Nanshan Zhong,
- Huahao Shen
Affiliations
- Fugui Yan
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Wen Li
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Wei‐jie Guan
- Department of Respiratory Medicine State Key Laboratory of Respiratory Disease Guangzhou Institute for Respiratory Health First Affiliated Hospital of Guangzhou Medical University Guangzhou China
- Min Chen
- Department of Respiratory Medicine Affiliated Hospital Guangdong Medical University Zhanjiang China
- Chen Qiu
- Department of Respiratory Medicine Shenzhen People's Hospital Shenzhen China
- Wei Tang
- Department of Respiratory Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China
- Xiansheng Liu
- Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China
- Xudong Xiang
- Department of Respiratory Medicine Second Xiangya Hospital Central South University Changsha China
- Jing Li
- Department of Allergy and Clinical Immunology Guangzhou Institute of Respiratory Health The First Hospital Guangzhou Medical University Guangzhou China
- Meiling Jin
- Department of Respiratory Medicine Zhongshan Hospital Fudan University Shanghai China
- Yuanrong Dai
- Department of Pulmonary Medicine Second Affiliated Hospital of Wenzhou Medical University Wenzhou China
- Ping Chen
- Department of Pulmonary Medicine General Hospital of Northern Theater Command of the Chinese People's Liberation Army Shenyang China
- Xiaohong Wu
- Department of Pulmonary Medicine Affiliated Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China
- Zhongmin Qiu
- Department of Pulmonary Medicine Tongji Hospital Tongji University School of Medicine Shanghai China
- Liang Dong
- Department of Pulmonary Medicine Qilu Hospital of Shandong University Jinan China
- Limin Zhao
- Department of Pulmonary Medicine Henan Provincial People's Hospital People's Hospital of Zhengzhou University Zhengzhou China
- Xiaoping Lin
- Department of Pulmonary Medicine Second Affiliated Hospital of Fujian Medical University Fujian China
- Changgui Wu
- Department of Respiratory Disease Xijing Hospital The Fourth Military Medical University Xian China
- Bin Wu
- Department of Respiratory Medicine Affiliated Hospital Guangdong Medical University Zhanjiang China
- Yalian Yuan
- Department of Respiratory Medicine Affiliated Hospital Guangdong Medical University Zhanjiang China
- Fei Shi
- Department of Respiratory Medicine Shenzhen People's Hospital Shenzhen China
- Ting Zhang
- Department of Respiratory Medicine Shenzhen People's Hospital Shenzhen China
- Jun Zhou
- Department of Respiratory Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China
- Min Xie
- Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China
- Xiaoyu Fang
- Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China
- Hongliang Zhang
- Department of Respiratory Medicine Second Xiangya Hospital Central South University Changsha China
- Bing Xiao
- Department of Respiratory Medicine Second Xiangya Hospital Central South University Changsha China
- Mo Xian
- Department of Allergy and Clinical Immunology Guangzhou Institute of Respiratory Health The First Hospital Guangzhou Medical University Guangzhou China
- Jian Wang
- Department of Respiratory Medicine Zhongshan Hospital Fudan University Shanghai China
- Zhangwei Qiu
- Department of Pulmonary Medicine Second Affiliated Hospital of Wenzhou Medical University Wenzhou China
- Jie Lin
- Department of Pulmonary Medicine Second Affiliated Hospital of Wenzhou Medical University Wenzhou China
- Bingbing Ji
- Department of Pulmonary Medicine General Hospital of Northern Theater Command of the Chinese People's Liberation Army Shenyang China
- Yong Zhou
- Department of Pulmonary Medicine Affiliated Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China
- Yu Li
- Department of Pulmonary Medicine Tongji Hospital Tongji University School of Medicine Shanghai China
- Chunhong Liu
- Department of Pulmonary Medicine Qilu Hospital of Shandong University Jinan China
- Yiping Chen
- Department of Pulmonary Medicine Henan Provincial People's Hospital People's Hospital of Zhengzhou University Zhengzhou China
- Yiming Zeng
- Department of Pulmonary Medicine Second Affiliated Hospital of Fujian Medical University Fujian China
- Lingli Liu
- Department of Respiratory Disease Xijing Hospital The Fourth Military Medical University Xian China
- Wen Hua
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Huaqiong Huang
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Jiesen Zhou
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Yue Hu
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Luanqing Che
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Songmin Ying
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Zhihua Chen
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- Nanshan Zhong
- Department of Respiratory Medicine State Key Laboratory of Respiratory Disease Guangzhou Institute for Respiratory Health First Affiliated Hospital of Guangzhou Medical University Guangzhou China
- Huahao Shen
- Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China
- DOI
- https://doi.org/10.1002/ctm2.178
- Journal volume & issue
-
Vol. 10,
no. 5
pp. n/a – n/a
Abstract
Abstract Background Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. Objective The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. Results After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258‐0.625, P<.001). Furthermore, at week 52, FVC, FEV1%, the diurnal variation in PEFand the PD20‐FEV1 were significantly improved. Subgroup analysis revealed that the patients at first administration in the responsive group had higher ACQ‐5 scores than those in the nonresponsive group (P < .05). Conclusion In conclusion, patients with CTVA had a good therapeutic response to the guideline‐recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ‐5 scores had better therapeutic effects.
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