Communications Biology (Sep 2022)

Low-dose radiation exaggerates HFD-induced metabolic dysfunction by gut microbiota through PA-PYCR1 axis

  • Zhao Ju,
  • Peiyu Guo,
  • Jing Xiang,
  • Ridan Lei,
  • Guofeng Ren,
  • Meiling Zhou,
  • Xiandan Yang,
  • Pingkun Zhou,
  • Ruixue Huang

DOI
https://doi.org/10.1038/s42003-022-03929-1
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 17

Abstract

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Characterisation of gut microbiota shows that low-dose radiation enhances the metabolic defects induced by high-fat diet in mice, in a manner involving increased levels of pyrrolidinecarboxylic acid.