Case report: Acute Talaromyces marneffei mediastinitis in an HIV-negative patient

Liangyu Chen; Liangyu Chen; Liangyu Chen; Meichun Zhang; Meichun Zhang; Weihong Guo; Weihong Guo; Wenshuang Ding; Wenshuang Ding; Jinwen Tan; Jinwen Tan; Hong Du; Hong Du; Ziwen Zhao; Ziwen Zhao; Weinong Zhong; Weinong Zhong

doi:10.3389/fmicb.2022.1045660

Frontiers in Microbiology (Nov 2022)

Case report: Acute Talaromyces marneffei mediastinitis in an HIV-negative patient

Liangyu Chen,
Liangyu Chen,
Liangyu Chen,
Meichun Zhang,
Meichun Zhang,
Weihong Guo,
Weihong Guo,
Wenshuang Ding,
Wenshuang Ding,
Jinwen Tan,
Jinwen Tan,
Hong Du,
Hong Du,
Ziwen Zhao,
Ziwen Zhao,
Weinong Zhong,
Weinong Zhong

Affiliations

Liangyu Chen: Department of Respiratory and Critical Care Medicine, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China
Liangyu Chen: Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China
Liangyu Chen: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Meichun Zhang: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Meichun Zhang: South China University of Technology, Guangzhou, China
Weihong Guo: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Weihong Guo: South China University of Technology, Guangzhou, China
Wenshuang Ding: South China University of Technology, Guangzhou, China
Wenshuang Ding: Department of Pathology, Guangzhou First People's Hospital, Guangzhou, China
Jinwen Tan: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Jinwen Tan: South China University of Technology, Guangzhou, China
Hong Du: South China University of Technology, Guangzhou, China
Hong Du: Department of Pathology, Guangzhou First People's Hospital, Guangzhou, China
Ziwen Zhao: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Ziwen Zhao: South China University of Technology, Guangzhou, China
Weinong Zhong: Department of Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou, China
Weinong Zhong: South China University of Technology, Guangzhou, China

DOI: https://doi.org/10.3389/fmicb.2022.1045660
Journal volume & issue: Vol. 13

Abstract

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Talaromyces marneffei (T. marneffei) is one of the most important opportunistic human pathogens endemic in Southeast Asia. Talaromycosis, which was once regarded as an opportunistic infectious disease in patients with acquired immunodeficiency syndrome, is being increasingly reported in HIV-negative populations. Since T. marneffei infection can be localized or disseminated, patients may present with a variety of symptoms. However, mediastinal infection attributed to T. marneffei is extremely rare. We report the case of a 32-year-old female who manifested a large mediastinal mass and was eventually diagnosed as acute T. marneffei mediastinitis. The patient was HIV-negative and had no direct contact with intermediate hosts. We successfully managed to treat the patient with inhaled amphotericin B deoxycholate and observed lesion absorption in subsequent CT examinations. To our knowledge, this is the first published case of T. marneffei mediastinitis and first use of inhaled antifungal monotherapy on patients with T. marneffei infection.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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