The state of the hemocoagulation system and endothelial dysfunction in benign and malignant skeleton neoplasms

Abstract

Aim: to study the functional status of the vascular endothelium and the activity of the hemocoagulation system, as well as the relationship between some indicators characterizing their state in patients with benign and malignant skeleton neoplasms. Material and Methods. 62 patients with benign (45) and malignant (17) bone neoplasms and 10 healthy individuals of the control group were examined. The coagulation properties of blood plasma and the content of vascular endothelial growth factor (VEGF), intercellular adhesion molecules of sICAM and adhesion molecules of vascular endothelium (sVCAM) in blood serum were investigated. Results. In patients with benign bone tumors, prothrombinase formation mechanisms were activated, the concentration of soluble fibrin-monomer complexes (FSC) was

Keywords

• benign and malignant tumors
• blood coagulation properties
• bone
• soluble adhesion molecules of vascular endofhelium type I (sVCAM)
• soluble intercellular adhesion molecules type I (sICAM)
• vascular endothelial growth factor A (VEGF-A)