Journal of Personalized Medicine (Jun 2021)
Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
- Diego Santos-García,
- Teresa de Deus,
- Carlos Cores,
- Hector Canfield,
- Jose M Paz González,
- Cristina Martínez Miró,
- Lorena Valdés Aymerich,
- Ester Suárez,
- Silvia Jesús,
- Miquel Aguilar,
- Pau Pastor,
- Lluis Planellas,
- Marina Cosgaya,
- Juan García Caldentey,
- Nuria Caballol,
- Ines Legarda,
- Jorge Hernández-Vara,
- Iria Cabo,
- Lydia López Manzanares,
- Isabel González Aramburu,
- Maria A Ávila Rivera,
- Maria J Catalán,
- Victor Nogueira,
- Victor Puente,
- Julio Dotor,
- Carmen Borrué,
- Berta Solano,
- Maria Álvarez Sauco,
- Lydia Vela,
- Sonia Escalante,
- Esther Cubo,
- Francisco Carrillo,
- Juan C Martínez Castrillo,
- Pilar Sánchez Alonso,
- Gemma Alonso,
- Nuria López Ariztegui,
- Itziar Gastón,
- Jaime Kulisevsky,
- Marta Blázquez,
- Manuel Seijo,
- Javier Rúiz Martínez,
- Caridad Valero,
- Monica Kurtis,
- Oriol de Fábregues,
- Jessica Ardura,
- Ruben Alonso,
- Carlos Ordás,
- Luis M López Díaz,
- Darrian McAfee,
- Pablo Martinez-Martin,
- Pablo Mir,
- COPPADIS Study Group
Affiliations
- Diego Santos-García
- CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
- Teresa de Deus
- CHUF, Complejo Hospitalario Universitario de Ferrol, 15405 A Coruña, Spain
- Carlos Cores
- CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
- Hector Canfield
- CHUF, Complejo Hospitalario Universitario de Ferrol, 15405 A Coruña, Spain
- Jose M Paz González
- CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
- Cristina Martínez Miró
- CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
- Lorena Valdés Aymerich
- CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
- Ester Suárez
- CHUF, Complejo Hospitalario Universitario de Ferrol, 15405 A Coruña, Spain
- Silvia Jesús
- Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41009 Seville, Spain
- Miquel Aguilar
- Hospital Universitari Mutua de Terrassa, 08221 Barcelona, Spain
- Pau Pastor
- Hospital Universitari Mutua de Terrassa, 08221 Barcelona, Spain
- Lluis Planellas
- Hospital Clínic de Barcelona, 08036 Barcelona, Spain
- Marina Cosgaya
- Hospital Clínic de Barcelona, 08036 Barcelona, Spain
- Juan García Caldentey
- Centro Neurológico Oms 42, 07003 Palma de Mallorca, Spain
- Nuria Caballol
- Consorci Sanitari Integral, Hospital Moisés Broggi, 08970 Barcelona, Spain
- Ines Legarda
- Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain
- Jorge Hernández-Vara
- Hospital Universitario Vall d’Hebron, 08035 Barcelona, Spain
- Iria Cabo
- Complejo Hospitalario Universitario de Pontevedra (CHOP), 36071 Pontevedra, Spain
- Lydia López Manzanares
- Hospital Universitario La Princesa, 28006 Madrid, Spain
- Isabel González Aramburu
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 28031 Madrid, Spain
- Maria A Ávila Rivera
- Consorci Sanitari Integral, Hospital General de L’Hospitalet, 08906 Barcelona, Spain
- Maria J Catalán
- Hospital Universitario Clínico San Carlos, 28040 Madrid, Spain
- Victor Nogueira
- Hospital Da Costa, 27880 Burela, Spain
- Victor Puente
- Hospital del Mar, 08003 Barcelona, Spain
- Julio Dotor
- Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
- Carmen Borrué
- Hospital Infanta Sofía, 28702 Madrid, Spain
- Berta Solano
- Institut d’Assistència Sanitària (IAS)—Institut Català de la Salut, 17190 Girona, Spain
- Maria Álvarez Sauco
- Hospital General Universitario de Elche, 03203 Elche, Spain
- Lydia Vela
- Fundación Hospital de Alcorcón, 28922 Madrid, Spain
- Sonia Escalante
- Hospital de Tortosa Verge de la Cinta (HTVC), 43500 Tarragona, Spain
- Esther Cubo
- Complejo Asistencial Universitario de Burgos, 09006 Burgos, Spain
- Francisco Carrillo
- Hospital Universitario de Canarias, 38320 San Cristóbal de la Laguna, Spain
- Juan C Martínez Castrillo
- Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, Spain
- Pilar Sánchez Alonso
- Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain
- Gemma Alonso
- Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), 36213 Vigo, Spain
- Nuria López Ariztegui
- Complejo Hospitalario de Toledo, 45071 Toledo, Spain
- Itziar Gastón
- Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
- Jaime Kulisevsky
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 28031 Madrid, Spain
- Marta Blázquez
- Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
- Manuel Seijo
- Complejo Hospitalario Universitario de Pontevedra (CHOP), 36071 Pontevedra, Spain
- Javier Rúiz Martínez
- Hospital Universitario Donostia, 20009 San Sebastián, Spain
- Caridad Valero
- Hospital Arnau de Vilanova, 46015 Valencia, Spain
- Monica Kurtis
- Hospital Ruber Internacional, 28034 Madrid, Spain
- Oriol de Fábregues
- Hospital Universitario Vall d’Hebron, 08035 Barcelona, Spain
- Jessica Ardura
- Hospital de Cabueñes, 33394 Gijón, Spain
- Ruben Alonso
- Hospital Universitario Lucus Augusti (HULA), 27002 Lugo, Spain
- Carlos Ordás
- Hospital Rey Juan Carlos, 28933 Madrid, Spain
- Luis M López Díaz
- Complejo Hospitalario Universitario de Orense (CHUO), 32005 Orense, Spain
- Darrian McAfee
- Laboratory for Cognition and Neural Stimulation, Univeristy of Pennsylvania, Philadelphia, PA 19104, USA
- Pablo Martinez-Martin
- CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 28031 Madrid, Spain
- Pablo Mir
- Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41009 Seville, Spain
- COPPADIS Study Group
- DOI
- https://doi.org/10.3390/jpm11070626
- Journal volume & issue
-
Vol. 11,
no. 7
p. 626
Abstract
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.
Keywords