The Roles of circRNAs in Liver Cancer Immunity

Ying Tang; Ying Tang; Ying Tang; Mei Jiang; Hai-Mei Jiang; Hai-Mei Jiang; Hai-Mei Jiang; Zeng Jie Ye; Yu-Sheng Huang; Xiu-Shen Li; Xiu-Shen Li; Xiu-Shen Li; Bin-Yu Qin; Rui-Sheng Zhou; Rui-Sheng Zhou; Hua-Feng Pan; Da-Yong Zheng; Da-Yong Zheng; Da-Yong Zheng

doi:10.3389/fonc.2020.598464

Frontiers in Oncology (Feb 2021)

The Roles of circRNAs in Liver Cancer Immunity

Ying Tang,
Ying Tang,
Ying Tang,
Mei Jiang,
Hai-Mei Jiang,
Hai-Mei Jiang,
Hai-Mei Jiang,
Zeng Jie Ye,
Yu-Sheng Huang,
Xiu-Shen Li,
Xiu-Shen Li,
Xiu-Shen Li,
Bin-Yu Qin,
Rui-Sheng Zhou,
Rui-Sheng Zhou,
Hua-Feng Pan,
Da-Yong Zheng,
Da-Yong Zheng,
Da-Yong Zheng

Affiliations

Ying Tang: Department of Oncology, Institute of Tumor, Guangzhou University of Chinese Medicine, Guangzhou, China
Ying Tang: Department of Oncology, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China
Ying Tang: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Mei Jiang: Department of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Hai-Mei Jiang: Department of Oncology, Institute of Tumor, Guangzhou University of Chinese Medicine, Guangzhou, China
Hai-Mei Jiang: Department of Oncology, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China
Hai-Mei Jiang: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Zeng Jie Ye: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Yu-Sheng Huang: Department of Oncology, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China
Xiu-Shen Li: Department of Oncology, Institute of Tumor, Guangzhou University of Chinese Medicine, Guangzhou, China
Xiu-Shen Li: Department of Oncology, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China
Xiu-Shen Li: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Bin-Yu Qin: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Rui-Sheng Zhou: Department of Oncology, Institute of Tumor, Guangzhou University of Chinese Medicine, Guangzhou, China
Rui-Sheng Zhou: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Hua-Feng Pan: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Da-Yong Zheng: Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, China
Da-Yong Zheng: Department of Hepatopancreatobiliary, Cancer Center, Southern Medical University, Guangzhou, China
Da-Yong Zheng: Department of Hepatology, TCM-Integrated Hospital of Southern Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fonc.2020.598464
Journal volume & issue: Vol. 10

Abstract

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Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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