Different macaque brain network remodeling after spinal cord injury and NT3 treatment
Ting Feng,
Can Zhao,
Jia-Sheng Rao,
Xiao-Jun Guo,
Shu-Sheng Bao,
Le-Wei He,
Wen Zhao,
Zuxiang Liu,
Zhao-Yang Yang,
Xiao-Guang Li
Affiliations
Ting Feng
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Can Zhao
Institute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing, PR China
Jia-Sheng Rao
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding author
Xiao-Jun Guo
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Shu-Sheng Bao
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Le-Wei He
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Wen Zhao
Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR China
Zuxiang Liu
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, PR China; Department of Biology, College of Life Sciences, University of Chinese Academy of Sciences, Beijing, PR China; Corresponding author
Zhao-Yang Yang
Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR China; Corresponding author
Xiao-Guang Li
School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding author
Summary: Graph theory-based analysis describes the brain as a complex network. Only a few studies have examined modular composition and functional connectivity (FC) between modules in patients with spinal cord injury (SCI). Little is known about the longitudinal changes in hubs and topological properties at the modular level after SCI and treatment. We analyzed differences in FC and nodal metrics reflecting modular interaction to investigate brain reorganization after SCI-induced compensation and neurotrophin-3 (NT3)–chitosan-induced regeneration. Mean inter-modular FC and participation coefficient of areas related to motor coordination were significantly higher in the treatment animals than in the SCI-only ones at the late stage. The magnocellular part of the red nucleus may reflect the best difference in brain reorganization after SCI and therapy. Treatment can enhance information flows between regions and promote the integration of motor functions to return to normal. These findings may reveal the information processing of disrupted network modules.
