International Journal of General Medicine (Nov 2022)
The Role of Serum 1,25-Dihydroxy Vitamin D3 and PCT in Idiopathic Pulmonary Fibrosis
Abstract
Li Yang,1 Zhinan Zhai,2 Jinxiang Zhang3 1Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, People’s Republic of China; 2Department of Medical Laboratory Science, Tianjin Chest Hospital, Tianjin, People’s Republic of China; 3Department of Nutrition, Tianjin Chest Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Li Yang, Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, No. 261 Taierzhuang South Road, Jinnan District, Tianjin, 300222, People’s Republic of China, Tel +86 22-88185009, Email [email protected]: Biomarkers for the acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) are urgently needed to provide better patient management. We aimed to investigate whether serum 1,25(OH)2D3 (1,25-dihydroxy vitamin D3) levels predict AE-IPF and whether they could be a potential prognostic biomarker for IPF.Participants and Methods: This prospective study included 72 patients with IPF (31 with stable IPF and 41 with AE-IPF). All participants were recruited during hospitalisation at Tianjin Chest Hospital and were followed up for at least 12 months. Demographics, comorbidities, arterial blood gas, and serum biochemical profile, radiological features, and anti-fibrotic therapy were evaluated. Serum concentrations of 1,25(OH)2D3 and transforming growth factor beta1 (TGFβ 1) were detected using enzyme-linked immunosorbent assay (ELISA). Risk factors for AE-IPF were identified using multivariate analysis. Prognostic factors were assessed using Kaplan-Meier and Cox regression analyses.Results: Baseline values of alveolar-arterial oxygen difference (A-aDO2) (40.85 mmHg vs 29.2 mmHg, p =0.035), white blood cell counts (10.09 ± 4.2× 109/L vs 7.46 ± 7.84× 109/L, p 0.05 ng/mL) was associated with an increased risk of mortality (HR 3.664, 95% CI 1.010– 12.900, p =0.043).Conclusion: Decreased serum 1,25(OH)2D3 is associated with an increased risk of acute exacerbation for patients with IPF. A high serum PCT level is predictive of worse prognosis in IPF patients. 1,25(OH)2D3 may be a potential biomarker for AE-IPF, while PCT could be a prognostic biomarker for IPF.Keywords: idiopathic pulmonary fibrosis, acute exacerbation, 1,25(OH)2D3, procalcitonin
