Nature Communications (Apr 2018)
Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival
- Megumi Shiota,
- Masayuki Naya,
- Takehiro Yamamoto,
- Takako Hishiki,
- Takeharu Tani,
- Hiroyuki Takahashi,
- Akiko Kubo,
- Daisuke Koike,
- Mai Itoh,
- Mitsuyo Ohmura,
- Yasuaki Kabe,
- Yuki Sugiura,
- Nobuyoshi Hiraoka,
- Takayuki Morikawa,
- Keiyo Takubo,
- Kentaro Suina,
- Hideaki Nagashima,
- Oltea Sampetrean,
- Osamu Nagano,
- Hideyuki Saya,
- Shogo Yamazoe,
- Hiroyuki Watanabe,
- Makoto Suematsu
Affiliations
- Megumi Shiota
- Frontier Core-Technology Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
- Masayuki Naya
- Frontier Core-Technology Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
- Takehiro Yamamoto
- Department of Biochemistry, Keio University School of Medicine
- Takako Hishiki
- Department of Biochemistry, Keio University School of Medicine
- Takeharu Tani
- Frontier Core-Technology Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
- Hiroyuki Takahashi
- Analysis Technology Center, Research & Development Management Headquarters, FUJIFILM Corporation
- Akiko Kubo
- Department of Biochemistry, Keio University School of Medicine
- Daisuke Koike
- Functional Materials R&D Support Department, Research & Development Process Services Division, FUJIFILM Business Expert Corporation
- Mai Itoh
- Department of Biochemistry, Keio University School of Medicine
- Mitsuyo Ohmura
- Department of Biochemistry, Keio University School of Medicine
- Yasuaki Kabe
- Department of Biochemistry, Keio University School of Medicine
- Yuki Sugiura
- Department of Biochemistry, Keio University School of Medicine
- Nobuyoshi Hiraoka
- Pathology Division, National Cancer Center Research Institute
- Takayuki Morikawa
- Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine
- Keiyo Takubo
- Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine
- Kentaro Suina
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Hideaki Nagashima
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Oltea Sampetrean
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Osamu Nagano
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Hideyuki Saya
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Shogo Yamazoe
- Frontier Core-Technology Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
- Hiroyuki Watanabe
- Frontier Core-Technology Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
- Makoto Suematsu
- Department of Biochemistry, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03899-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Surface-enhanced Raman spectroscopy (SERS) visualizes fingerprints of intermolecular vibrations of many metabolites. Here the authors report a SERS imaging technique that enables the visualization of metabolites distribution and automated extraction of tumour boundaries in frozen tissues.
