Nature Communications (Sep 2017)

Identification of HSP90 inhibitors as a novel class of senolytics

  • Heike Fuhrmann-Stroissnigg,
  • Yuan Yuan Ling,
  • Jing Zhao,
  • Sara J. McGowan,
  • Yi Zhu,
  • Robert W. Brooks,
  • Diego Grassi,
  • Siobhan Q. Gregg,
  • Jennifer L. Stripay,
  • Akaitz Dorronsoro,
  • Lana Corbo,
  • Priscilla Tang,
  • Christina Bukata,
  • Nadja Ring,
  • Mauro Giacca,
  • Xuesen Li,
  • Tamara Tchkonia,
  • James L. Kirkland,
  • Laura J. Niedernhofer,
  • Paul D. Robbins

DOI
https://doi.org/10.1038/s41467-017-00314-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of a HSP90 inhibitor reduces age-related symptoms in progeroid mice.