Treatment of COVID-19-Releated Hyperinflammatory Response In Intensive Care Unit: Pulse Steroid, Anticytokines, IVIG, Plasmapheresis.

Abstract

ABSTRACT AIM: In our study, we aimed to see whether there is a difference in the survival effects of the treatments in 144 covid-19 patients who developed HIS. MATERIAL and METHODS: Between Nov 2020 and Jan 2021; we retrospectively evaluated 323 patients who were admitted in to intensive care unit (ICU). Among these patients, we analyzed 144 patients whom recieved pulse steroid, anticytokine, plasmapheresis and IVIG treatment alone or in combination (1). The demographic characteristics of the patients are demonstrated in table 1. The treatment planning of Covid-19 in our hospital is organized and implemented by a multidisciplinary treatment board. Accordingly, pulse was administered to patients whom had shown HIS findings after the day 7 of the initial diagnosis. If there is no contraindication; transition to anticytokine treatment and then plasmapheresis and / or IVIG was applied (2,3). RESULTS: When all the treatments were examined, no difference was found between the survival rates according to the application. While the mortality rate was %68 in all patients hospitalized in our ICU’s with Covid-19, this rate was found to be %81 in our patients with HIS. CONCLUSION: There is an obvious condition that an amount of time is needed for supposed positive results of our admitted treatments. While our mortality rate was lower in all patients we followed up; in accordance with our expectations, we can say that the mortality rate is high in patients with HIS. The fact that no superiority of treatment modalities was observed in our study; we can still attribute the fact that the clinics of Covid-19 patients are not homogeneous and that there is no definite standardization regarding treatment yet.

Keywords

• covid-19
• icu
• ards
• hyperinflammatory response
• steroid
• covid-19
• icu
• ards
• hiperinflamatuvar yanıt
• steroid