Nature Communications (Jun 2020)

Tetrameric architecture of an active phenol-bound form of the AAA+ transcriptional regulator DmpR

  • Kwang-Hyun Park,
  • Sungchul Kim,
  • Su-Jin Lee,
  • Jee-Eun Cho,
  • Vinod Vikas Patil,
  • Arti Baban Dumbrepatil,
  • Hyung-Nam Song,
  • Woo-Chan Ahn,
  • Chirlmin Joo,
  • Seung-Goo Lee,
  • Victoria Shingler,
  • Eui-Jeon Woo

DOI
https://doi.org/10.1038/s41467-020-16562-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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DmpR is a bacterial enhancer binding protein from the AAA+ family of ATPases that binds aromatic compounds and controls the transcription of genes involved in the degradation of toxic pollutants. Here, the authors present the crystal structure of phenol-bound DmpR, which forms a tetramer and discuss its signal transduction mechanism.